Organizer:
Nir Ben-Tal (TAU, Israel)

This one-day workshop will bring together an international group of experts to discuss functional aspects of genome annotation. The workshop goals are to create an open forum to discuss current problems on function annotation, to foster the analysis of key scientific issues in function prediction, and to promote collaboration among scientists interested in the development of computational methods in this key area of molecular biology.


Workshop 2: Genome Annotation: a BioSapiens Network of Excellence Initiative
Program
10:00 - 10:05 Welcome: Nir Ben-Tal (TAU, Israel)
10:05 - 10:15 About BioSapiens: Anna Tramontano (Univ. of Rome, Italy)
Session 1: Large-scale studies of membrane proteins (Chair: Nir Ben-Tal, TAU, Israel)
10:15 - 10:45 Diana Murray (Cornell, USA): Genomic and proteomic analysis of peripheral membrane proteins.
10:45 - 11:15 Arne Elofsson (Stockholm, Sweden): Extending the goals of membrane protein predictions
11:15 - 11:45 Rita Casadio (Bologna, Italy): How many membrane proteins are there in the human genome?
11:45 - 12:15 Coffee break and poster viewing

Session 2: Whole-genome annotation (Chair: Tal Pupko, TAU, Israel)
12:15 - 12:45 Dmitrij Frishman (GSF, Germany): Mining biological databanks for association patterns
12:45 - 13:15 Michal Linial (HUJI, Israel): Automatic functional annotation scheme: Testing new genomes and revisiting old ones
13:15 - 13:45 Burkhard Rost (Columbia, USA): Evolution teaches protein function prediction
13:45 - 14:15

David Horn (TAU, Israel): Functional representation of enzymes by specific peptides

14:15 - 15:00 Lunch

Session 3: Alternative splicing (Chair: Mikhail Gelfand, IITP, Russia)
15:00 - 15:30 Roderic Guigo (IMIM, Spain): Annotation of Selenoprotein Genes in Eukaryotic Genomes
15:30 - 16:00 Alfonso Valencia (CNIO, Spain): Analysis of the protein complement of the ENCODE region
16:00 - 16:30 Gil Ast (TAU, Israel): How did alternative splicing evolve?
16:30 - 17:00 Coffee break and poster viewing

Session 4: Structural genomics (Chair: Anna Tramontano, Univ. of Rome, Italy)
17:00 - 17:30 Barry Honig (Columbia, USA): Assigning function from apparently remote sequence and structural relationships
17:30 - 18:00 Allegra Via (Roma Tor Vergata, Italy): High-throughput protein functional annotation based upon local structure similarity
18:00 - 18:30 Christine Orengo (UCL, UK): Structural and comparative genomics to reveal protein functions

Session 5: Cross-indexing between biological databases
(Chairs: Shifra Ben-Dor, Weizmann Institute, Israel and Roded Sharan, Tel Aviv University, Israel)
18:30 - 18:55 Initial presentations by the chairs, followed by an open discussion about possible solutions to this problem and how to achieve them
18:55 - 19:00 Farewell: Nir Ben-Tal
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